Phenotype Image Detail

Image

Caption

Cerebellar abnormalities in Braf^tm2Urr/Braf^tm2Urr Tg(Nes-cre)1Kln/0 and Braf^tm2.1Urr/Braf^tm2.1Urr Tg(Nes-cre)1Kln/0 (cKO) mice. (A, A') Representative sagittal sections of P21 cerebellum stained with haematoxylin and eosin (HE) are shown in the upper panel. (B, B') HE-stained pictures display the reduced size of lobe X with disorganized glomeruli. (C, C') Calbindin staining was used to visualize the elongated primarydendrite and reduced and irregular arborization of Purkinje neurons in the molecular layer. Scale bars; 25 mm or as indicated.

This image is from Pfeiffer V, PLoS One 2013;8(3):e58259, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199842

Associated
Alleles

Symbol	Name
Braf^tm2.1Urr	Braf transforming gene; targeted mutation 2.1, Urr R Rapp
Braf^tm2Urr	Braf transforming gene; targeted mutation 2, Urr R Rapp
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated
Genotypes

Allelic Composition	Genetic Background
Braf^tm2.1Urr/Braf^tm2.1Urr Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL
Braf^tm2Urr/Braf^tm2Urr Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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