Phenotype Image Detail

Image

Caption

Cerebellar abnormalities in Braf^tm2Urr/Braf^tm2Urr Tg(Nes-cre)1Kln/0 and Braf^tm2.1Urr/Braf^tm2.1Urr Tg(Nes-cre)1Kln/0 (cKO) mice. (A, A') Representative sagittal sections of P21 cerebellum stained with haematoxylin and eosin (HE) are shown in the upper panel. (B, B') HE-stained pictures display the reduced size of lobe X with disorganized glomeruli. (C, C') Calbindin staining was used to visualize the elongated primarydendrite and reduced and irregular arborization of Purkinje neurons in the molecular layer. Scale bars; 25 mm or as indicated.

This image is from Pfeiffer V, PLoS One 2013;8(3):e58259, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199842

Associated
Alleles

Symbol	Name
Braf^tm2.1Urr	Braf transforming gene; targeted mutation 2.1, Urr R Rapp
Braf^tm2Urr	Braf transforming gene; targeted mutation 2, Urr R Rapp
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated
Genotypes

Allelic Composition	Genetic Background
Braf^tm2.1Urr/Braf^tm2.1Urr Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL
Braf^tm2Urr/Braf^tm2Urr Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * SJL

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24