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Phenotype Image Detail
Image
Caption 5C, H&E-stained liver sections from control (Alb Ei24f/+) and Ei24tm1Hzha/Ei24tm1Hzha Speer6-ps1Tg(Alb-cre)21Mgn/0 (Alb Ei24f/f) mutant mice show disorganized hepatic lobules and swollen hepatocytes. Insets show higher magnification views. Bar, 50 um. D, gross anatomy of livers from mutant mice at 10 months of age demonstrates the development of multiple tumor-like protrusions (arrows). E, H&E staining of liver sections from mutant mice at 10 months ofage (first panel). The arrow indicates a tumor-like protrusion. Bar, 100 um. Higher magnification images of livers from controls (second panel) and Ei24-deficient mice (third panel, protrusion region) at 10 months of age. Bar, 20 um.
Copyright This image is from Zhao YG, J Biol Chem 2012 Dec 7;287(50):42053-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193420
Associated
Alleles
Symbol Name
Ei24tm1Hzha etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
Speer6-ps1Tg(Alb-cre)21Mgn spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
Associated
Genotypes
Allelic Composition Genetic Background
Ei24tm1Hzha/Ei24tm1Hzha
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory