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| Caption | Uterine defects in Pgrtm4.2Lyd/Pgrtm4.2Lyd (PRd/d) and Pgrtm1Bwo/Pgrtm1Bwo (PRKO) mice. (a) At the macrolevel, a decidual reaction is clearly evident in the left (L) uterine horn of the hormone-treated wild-type (WT) mouse following the decidual stimulus; a decidual reaction was not detected in the unstimulated right (R) or control horn. (b, c) show that similarly treated Pgrtm1Bwo/Pgrtm1Bwo (PRKO) and Pgrtm4.2Lyd/Pgrtm4.2Lyd (PRd/d) uteri, respectively, do not exhibit a decidual response in the mechanically stimulated left horn. (d) Histogram displays the average ratio of wet weights of stimulated horn over control horn (+/- SEM) for WT (black column); PRKO (gray column); and PRd/d (white column) mouse groups. ***P < 0.001, one-way ANOVA followed by Tukey's post hoc multiple range test (N = 4 per genotype). (e-g) show representative uterine sections stained for BrdU incorporation from sesame oil treated ovariectomized WT, PRKO, and PRd/d mice, respectively. Note the absence of BrdU positive cells in the luminal epithelium (LE), glandular epithelium (GE), and stromal (S) compartments of the WT, PRKO, and PRd/d uterus. H, I, and J show representative uterine sections stained for BrdU incorporation from E2 treated WT, PRKO, and PRd/d mice, respectively. Arrowheads indicate the position of BrdU positive cells in the luminal epithelial compartment of uteri from all three genotypes. (k-m) show representative uterine sections stained for BrdU incorporation from E2P4 treated WT, PRKO, and PRd/d mice. Note that BrdU positive cells are absent in the luminal epithelial compartment of the E2P4 treated WT uterus, whereas a subset of stromal cells are positive for BrdU incorporation (arrowhead). However, only the luminal epithelial compartment is positive for BrdU incorporation in the E2P4-treated PRKO and PRd/d uterus [arrowhead in (l) and (m) respectively]. Scale bar in (e) applies to (f-m). | ||||||
| Copyright | This image is from Fernandez-Valdivia R, Genesis 2010 Feb;48(2):106-13, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:158406 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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