Phenotype Image Detail

Image

Caption

Morphometric analyses of the skulls of Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) and Fgfr2^tm1Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/S252W) mice. Euclidean Distance Matrix Analysis (EDMA) results from intra-model comparisons between mutant and normal littermates. From top to bottom: superior, lateral and inferior views of micro-CT 3D reconstructions of the skull of a Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 mouse on the left, and of a Fgfr2^tm1Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 mouse on the right. Red lines indicate linear distances that are significantly shorter in both mutants in comparison with their littermate controls, blue lines represent linear distances that are significantly longer in mutants in comparison to their littermate controls; and green lines show linear distances that are similar in mutants and littermate controls (i.e. no statistical differences at the alpha = 0.1 level).

This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773

Associated
Alleles

Symbol	Name
Fgfr2^tm1Ewj	fibroblast growth factor receptor 2; targeted mutation 1, Ethylin Wang Jabs
Fgfr2^tm2Ewj	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated
Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm2Ewj Tg(EIIa-cre)C5379Lmgd
Fgfr2^tm1Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm1Ewj Tg(EIIa-cre)C5379Lmgd

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