Phenotype Image Detail

Image

Caption

Impaired pancreatic epithelial growth and branching morphogenesis in Sel1l^{Gt(CA0017)Wtsi}/Sel1l^{Gt(CA0017)Wtsi} (-/-) embryos. (A-D) Immunohistological analysis of the developing pancreas of wild-type (WT) and mutant embryos at E11.5 and E13.5; the genotypes of the pancreatic sections are indicated as +/+ and -/-, respectively. The following antibodies were used: Pdx1 (A-D, green) and insulin (C-D, red). (A-B) The dorsal and ventral pancreatic buds in mutant embryosare fused together. (C-D) The dorsal pancreatic bud of mutant embryos exhibits a markedly reduced epithelial size and an impaired branching morphology.

This image is from Li S, BMC Dev Biol 2010;10():19, an open-access article, licensee BioMed Central Ltd. J:158780

Associated
Alleles

Symbol	Name
Sel1l^{Gt(CA0017)Wtsi}	sel-1 suppressor of lin-12-like (C. elegans); gene trap CA0017, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Sel1l^{Gt(CA0017)Wtsi}/Sel1l^{Gt(CA0017)Wtsi}	involves: 129P2/OlaHsd

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24