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| Caption | Reduced internuclear commissure in Robo3tm1.1Ache/Robo3tm1.1Ache Egr2tm2(cre)Pch/Egr2+ (Krox20::cre;Robo3lox/lox) mice. (A to I) show coronal hindbrain sections at the level of the abducens nucleus, visualized by Hb9 immunostaining (in A, D, E, F, and H). (A, B, and C) illustrate the projection of abducens axons (arrowheads) across the midline (dashed line) in Robo3+/- E13 embryos. Some GFP+ axons originate from the abducens nucleus (VI) and are immunoreactive for Robo3 (B and C). (D) The internuclear commissure (arrowhead) is also observed in P0 controls, following Dil injection at the level of the oculomotor nucleus III. (E) This commissure is almost completely absent in P0 Robo3tm1.1Ache/Robo3tm1.1Ache Egr2tm2(cre)Pch/Egr2+ mice (arrowhead). (VIIn): Genu of facial nerve. (F to I) At E15, many neurofilament+ axons cross the midline at the VI level (arrowheads) in control embryo (F and G), whereas they are rare in the mutant embryo (H and I). Scale bars represent 100 um, except in (G and I), where they indicate 50 um. | ||||||
| Copyright | This image is from Renier N, PLoS Biol 2010;8(3):e1000325, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158918 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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