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| Caption | Phenotype of inferior olivary neurons in Ptf1atm1.1(cre)Cvw/Ptf1a+ Robo3tm1.1Ache/Robo3tm1.1Ache (Ptf1a::cre;Robo3lox/lox) mice. (A-F) Coronal sections of P0 (A, B, D, and E) and E13.5 (C and F) hindbrain at the level of the inferior olive labeled with Brn3.2 (A-F) and calbindin (A and D). The structure of the inferior olivary nucleus is disorganized in the conditional mutant mice (compare [A and B] with [D and E]), and many of its subdivisions have an abnormal shape. The arrows in (D) show the position of dorsal cap of Kooy (DC in [A]) and the Beta nucleus (Beta in [A]) neurons, and the arrows in (E) indicate the disorganized principal olive (PO in [B]). (C and F) Brn3.2+ IO neurons do not cross the midline (arrow) in either control (C) or mutant (F) embryos. The arrowheads point to migrating LRN neurons. (G) is a 1.16-um-thick confocal image of Dil-labeled IO neurons in control P0 mouse with Hoechst counterstaining. (H and I) Schematic representation of the olivocerebellar projection in control (H) and mutant mice (I). In control, all IO neurons project across the ventral midline to the contralateral cerebellum (Cer) where their terminal arborization, the climbing fibers (CF), synapse on Purkinje cells. In mutant mice, most IO axons project into the ipsilateral cerebellar cortex. Scale bars represent 100 um, except in (G), where it indicates 20 um a, b, and c indicate the subnuclei a, b, and c, respectively, of the MAO, DAO, dorsal accessory olive; DC, Dorsal Cap of Kooy; MAO, medial accessory olive. | ||||||
| Copyright | This image is from Renier N, PLoS Biol 2010;8(3):e1000325, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158918 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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