Phenotype Image Detail

Image

Caption

Absence of liver SLC2A2 (GLUT2) expression suppresses hepatic glucose uptake but does not impair endogenous glucose production. (A) PET imaging of ¹⁸FDG uptake by the liver and kidneys of control and Slc2a2^tm2Thor/Slc2a2^tm2Thor Alb^{tm1(cre/ERT2)Mtz}/Alb^{tm1(cre/ERT2)Mtz} (LG2KO) mice during the first 15 minutes after injection (dorsal view; red, high uptake; green, low uptake).

This image is from Seyer P, J Clin Invest 2013 Apr 1;123(4):1662-76 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:197607

Associated
Alleles

Symbol	Name
Alb^{tm1(cre/ERT2)Mtz}	albumin; targeted mutation 1, Daniel Metzger
Slc2a2^tm2Thor	solute carrier family 2 (facilitated glucose transporter), member 2; targeted mutation 2, Bernard Thorens

Associated
Genotypes

Allelic Composition	Genetic Background
Alb^{tm1(cre/ERT2)Mtz}/Alb^{tm1(cre/ERT2)Mtz} Slc2a2^tm2Thor/Slc2a2^tm2Thor	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

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