Phenotype Image Detail

Image

Caption

Analysis of limb and diaphragm muscles of the Col6a3^tm1Chu/Col6a3^tm1Chu (hm/hm) mouse mutant. A, cryosections of gastrocnemius (Gas), quadriceps (Qua), and diaphragm (Dia) muscles of wild-type (+/+) and homozygous mutant mice (hm/hm) were stained with hematoxylin and eosin. Centrally localized nuclei (arrows) are abundant in the homozygous mutant muscles but barely detectable in the wild-type controls. An increase in the interstitial connective tissue between muscle fibers is evident in the homozygous mutant mice compared with the wild-type control. Magnification bars, 50 um. D, increased immunoreactivity of type I collagen in homozygous mutant muscle. Cryosections of quadriceps muscles from 6-month-old wild-type and mutantmice were immunostained with affinity-purified antibody against type I collagen. A representative image is shown.

This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581

Associated
Alleles

Symbol	Name
Col6a3^tm1Chu	collagen, type VI, alpha 3; targeted mutation 1, Mon-Li Chu

Associated
Genotypes

Allelic Composition	Genetic Background
Col6a3^tm1Chu/Col6a3^tm1Chu	B6.129-Col6a3^tm1Chu

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