Phenotype Image Detail

Image

Caption

Lung sections from Edn2^tm1Ywa/Edn2^tm1Ywa (Et2 KO; P1-P21) and adult Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 (Et2^f/f;CAGGCre) (8-week-old) mice and their control littermates were stained with H&E. Lungs of Edn2^tm1Ywa/Edn2^tm1Ywa mice exhibited enlarged air spaces with substantial simplification of lung alveolar structure compared with WT controls. Similiar morphological changes were also observed in adult Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 mice. Original magnification, X10.

This image is from Chang I, J Clin Invest 2013 Jun 3;123(6):2643-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201436

Associated
Alleles

Symbol	Name
Edn2^tm1.1Nat	endothelin 2; targeted mutation 1.1, Jeremy Nathans
Edn2^tm1Ywa	endothelin 2; targeted mutation 1, Masashi Yanagisawa
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon

Associated
Genotypes

Allelic Composition	Genetic Background
Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Edn2^tm1Ywa/Edn2^tm1Ywa	involves: 129S6/SvEvTac

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24