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| Caption | Loss of Yap in Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO) mice results in lethal cardiomyopathy. (A) Progressive dilated cardiomyopathy in Yap cKO mice. H&E-stained four-chamber view sections of mouse hearts show gradual dilation of ventricular chambers and atrial thrombosis in mutant hearts, culminating in heart failure. (Scale bar: 1 mm) (B) Progressive deterioration of cardiac function in mutant mice with age, as evidenced by decreased fractionalshortening (FS). n = 4 per group. Data are mean +/- SD. *P < 0.05; **P < 0.005. | ||||||
| Copyright | This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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