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| Caption | Activated Yap enhances cardiac regeneration. (A) Masson's trichrome-stained heart sections of wild-type (WT) and Tg(Myh6-Yap1*S112A)#Eno/0 (Tg) mice at 21 days after left anterior descending coronary artery (LAD) ligation performed at P7. Serial sections were cut at 200-um intervals from the site of the ligature toward the apex. One representative WT and two Tg hearts are shown. The boundaries of the infarct zone are demarcated by the V-shaped lines on the right. (B) Masson's trichrome-stained heart sections of WT and Tg mice at 21 days after LAD ligation performed at P28. Serial sections were cut at 500-um intervals from the site of the ligature toward the apex. (C) Quantification of the fibrotic areas in heart sections shown in A. n = 3. (D) Quantification of the fibrotic areas in heart sections shown in B. n = 3 for WT; n = 4 for Tg. Fibrotic area (%) = (the sum of fibrotic area at levels 3 and 4/the sum of myocardial area in the left ventricular (LV) at levels 3 and 4) X100. Data are mean +/- SD. *P <0.05. | ||||
| Copyright | This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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