About   Help   FAQ
Phenotype Image Detail
Image
Caption Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 (EC-iDKO) and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 (EC-DKO) mice. (A and B) Representative wild-type (WT) or EC-iDKO mice bearing Lewis Lung carcinoma (LLC) tumors (A) or Melanoma tumors (B) at 18 days post inoculation of tumor cells. Dotted lines indicate tumors. (C) Representative WT or EC-DKO mice bearing LLC tumors at 18 days post inoculation of tumor cells. (D) Representative mouse brain T2-weighted images for WT and EC-iDKO gliomas, 24 days following GL261 cells injection.Images were acquired with a slice thickness of 0.5 mm and a FOV of 2 x 2 cm2, for an approximate in-plane resolution of 80 um. Dashed yellow lines mark tumors. (E) Longitudinally cut colon and rectum regions of WT and EC-iDKO mice challenged with azoxymethane (AOM) and dextran sodium sulphate (DSS). Mice were sacrificed after 18 weeks following treatment.
Copyright This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966
Associated
Alleles
Symbol Name
Epn1tm1.1Wami epsin 1; targeted mutation 1.1, Wang Min
Epn2tm1Ocr epsin 2; targeted mutation 1, Ottavio Cremona
Tg(Cdh5-cre)7Mlia transgene insertion 7, M Luisa Iruela-Arispe
Tg(Cdh5-cre/ERT2)CIVE23Mlia transgene insertion CIVE23, M Luisa Iruela-Arispe
Associated
Genotypes
Allelic Composition Genetic Background
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre/ERT2)CIVE23Mlia/0
involves: 129X1/SvJ * C57BL/6J
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0
involves: C57BL/6J * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory