Phenotype Image Detail

Image

Caption

Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) pups exhibit focal desquamation and abnormal epidermal histology. (A and B), Wild-type (Sgpp1^+/+) and Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) mice at 0.5 days (A) and 4 days after birth (B). The arrows in B indicate sites of desquamation. C-E, histology of mutant mouse skin. Paraffin sections of back skin from 2-day-old wild-type (C) and mutant (D and E) mice were stained with H&E. E represents a region of back skin undergoing peeling of the stratum corneum (marked by arrows) Bar, 200 um. SC, stratum corneum; SL, subcorneal layer.

This image is from Allende ML, J Biol Chem 2013 Jun 21;288(25):18381-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199597

Associated
Alleles

Symbol	Name
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene

Associated
Genotypes

Allelic Composition	Genetic Background
Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg}	involves: C57BL/6NTac

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24