About   Help   FAQ
Phenotype Image Detail
Image
Caption Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg (Sgpp1-/-) pups exhibit focal desquamation and abnormal epidermal histology. (A and B), Wild-type (Sgpp1+/+) and Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg (Sgpp1-/-) mice at 0.5 days (A) and 4 days after birth (B). The arrows in B indicate sites of desquamation. C-E, histology of mutant mouse skin. Paraffin sections of back skin from 2-day-old wild-type (C) and mutant (D and E) mice were stained with H&E. E represents a region of back skin undergoing peeling of the stratum corneum (marked by arrows) Bar, 200 um. SC, stratum corneum; SL, subcorneal layer.
Copyright This image is from Allende ML, J Biol Chem 2013 Jun 21;288(25):18381-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199597
Associated
Alleles
Symbol Name
Sgpp1tm1(KOMP)Vlcg sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1tm1(KOMP)Vlcg sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Associated
Genotypes
Allelic Composition Genetic Background
Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg involves: C57BL/6NTac

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory