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| Caption | Nlrp3tm3.1Hhf/Nlrp3+ (NOMID) mice exhibit stunted skeletal growth and reduced bone mass. X-ray radiography (A), DXA (B) or microCT analysis of the femur (C, E-H) of mutant and wild-type (WT) mice at age P13. DXA and microCT 3D reconstruction revealed generalized osteopenia and the presence of a tissue spike across the growth plate (C, arrowhead) in two mutant mice. (D) The metaphyseal region containing (E) or contiguous (F) to the spike (depicted in black in Fig. 3D) where trabecular bone volume (BV/TV) was quantified. BV/TV was unchanged in the metaphyseal region that included the spike, but was decreased in the region contiguous to this structure. Mutant mice also exhibited significantly lower cortical area (G) and thinner cortical bone (H). Quantitative data were obtained from 5-6 mice/genotype and expressed as the mean +/- S.E.M. *P<0.05; ** P<0.007. BMD, bone mineral density. | ||||
| Copyright | This image is from Bonar SL, PLoS One 2012;7(4):e35979, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:202147 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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