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| Caption | Abolishment of retinal ganglion cells (RGCs) in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 (Sox4/11-null) retinas. A-D, A'-D', F-I, F'-I', plastic sections of retinas isolated from 30-day-old control, Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 (Sox4-null) and Sox11tm1.1Gan/Sox11tm1.1Gan Tg(Six3-cre)69Frty/0 (Sox11-null) mice were analyzed by H&E staining (A, A', F, and F'), immunostaining of cryo-sections with anti-BRN3A (red) (B, B', G, and G'), immunostaining of whole-mount retina with anti-BRN3B (green) (C, C', H, and H') and SM132 (green) (D, D', I, and I'). K-N,K'-N', retinas of 14-day-old control mice and Sox4/11-null mice were analyzed with H&E staining (K and K'), immunostaining of cryo-sections with anti-BRN3A (red) (L, and L') and BRN3B (green) (M and M'). Immunostained sections with anti-BRN3A (red) and anti-BRN3B (green) were merged with DAPI staining pictures. E-E', J-J', O-O', ventral views of brains show thinner optic nerves (arrowheads) in Sox4-null and Sox11-null mice, and no optic nerves in Sox4/11-null mice. | ||||||||
| Copyright | This image is from Jiang Y, J Biol Chem 2013 Jun 21;288(25):18429-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199663 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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