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| Caption | Gross and microscopic pathology of hearts from Tg(Myh6-Gnaq*Q209L)52Ejne/? mice. (A) Gross morphology of hearts from 2-week-old (Upper) and 10-week-old (Lower) mutant mice (Left) and wild-type (WT) mice (Right). (Bar = 6 mm.) (B and C) Four-chamber sections of hearts from 2-week-old (B) and 10-week-old (C) mutant (Left) and WT mice (Right). (D-K) Comparison of myocardial histology in mutant (Upper) and WT mice (Lower) at 10 weeks. Atria from mutant mice showed thickened trabeculae and external wall thinning (D) with fibrosis (F), shown by collagen staining (blue). In ventricles from mutant mice hearts, there are myocyte (and nuclear) hypertrophic and degenerative changes (including intracellular vacuolization) (H) and diffuse interstitial fibrosis (J). (B-E, H, and I) Stained with hematoxylin and eosin. (F, G, J, and K) Stained with Masson's trichrome stain. [X4 (B and C); X33 (D-G); X66 (H-K).] | ||||
| Copyright | This image is from Mende U, Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13893-8. Copyright 1998 National Academy of Sciences, U.S.A. J:204274 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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