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| Caption | Morphological analysis showing reduced hepatic autophagy in starved Pld1tm1.1Gdp/Pld1tm1.1Gdp (Pld1 KO) mice. (a) Immunofluorescent detection of endogenous LC3 (red) in liver sections from fed or starved wild-type (WT) and mutant mice. Sections were counter-stained with DAPI. Scale bar, 5 um. (c) Electron microscopic analysis showing a reduction in the size and number of autophagosome/amphisome-like structures (AP) in mutant mice after food restriction. Representative electron micrographs from animals analysed in (a) showing APs (arrows) and autophagolysosomes/lysosomes (AL, arrowheads) in liver sections from starved WT and mutant mice. Insets show high magnification of the selected areas. Scale bar, 1 um. | ||||
| Copyright | This image is from Dall'Armi C, Nat Commun 2010;1():142, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:207283 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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