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Phenotype Image Detail
Image
Caption Myocardial ultrastructure. Masson's trichrome staining of cardiac muscle in wild-type mice (A) and Ndufs6Gt(AR0138)Wtsi/Ndufs6Gt(AR0138)Wtsi (Ndufs6gt/gt) mice (B), showing fibrosis in the latter as blue staining (arrow). Ultrastructure of myofibers and the nucleus are normal in left ventricular myocardium of wild-type mice (C) and mutant mice (D), but mitochondria in the latter contain central dense areas (arrows). Compared with wild-type mice (E), higher power reveals that myocardial mitochondria of mutant mice have tightly packed central cristae with diminished matrix space (F). [Scale bars, 0.1 mm (A and B); 1 um (C-F)].
Copyright This image is from Ke BX, Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6165-70. Copyright 2012 National Academy of Sciences, U.S.A. J:183619
Associated
Alleles
Symbol Name
Ndufs6Gt(AR0138)Wtsi NADH:ubiquinone oxidoreductase core subunit S6; gene trap AR0138, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Ndufs6Gt(AR0138)Wtsi/Ndufs6Gt(AR0138)Wtsi involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory