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| Caption | Inhibition of vascular development and midgestational lethality in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 (Z/Edn2;Sox2-Cre) embryos. (A and B) Dorsal view of E8.5 control and mutant embryos, showing mild growth retardation in the mutant embryo. (C and D) Lateral view of E9.5 control and mutant embryos, showing severe growth retardation in the mutant embryo, with pooling of blood in the head and thorax and dilated cardiac chambers (arrowhead in D). (E and F) Transverse sections of Toluidine Blue-stained E9.5 control and mutant embryos. (E) The control embryo has distinct atrial and ventricular chambers and a closed neural tube. (F) The mutant embryo has greatly enlarged and partially distinct atrial and ventricular chambers and an open neural tube. (Scale bar: 200 um.) (G and H) Flat-mount PECAM1 staining (with an HRP-conjugated secondary antibody and purple/black reaction product) of E9.5 control and mutant embryos. (G) The control embryo shows a well-organized segmental vasculature. (H) The mutant embryo shows minimal vascular development. (I and J) Deletion of Ednra can rescue the midgestational growth retardation of mutant embryos, which is shown by the normal appearance of the E14.5 Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 Ednratm2Ywa/Ednratm2Ywa (Z/Edn2; Sox2-Cre; Ednraf/-) embryo. | ||||||
| Copyright | This image is from Rattner A, Proc Natl Acad Sci U S A 2013 Oct 1;110(40):E3830-E3839. Copyright 2013 National Academy of Sciences, U.S.A. J:201133 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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