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| Caption | Absence of vascular defects in the brains of embryonic day 18 (E18) Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Foxg1tm1(cre)Skm/Foxg1+ (Z/Edn2;Foxg1-Cre) mice. (A and B) No alterations in CNS vascular architecture are apparent in E18 cerebral cortex of mutant mice relative to control mice as determined by GS-lectin staining. The cortical surface is to the right. (Scale bar: 200 um.) (C and D) Cleft palate (green arrow; the tongue is at the bottom center of the coronal section) and (E and F) open eyelids (green bracket) at E18 provide evidence that bioactive Edn2 is being produced in the heads of mutant mice. (C and D, scale bar: 200 um; E and F, scale bar: 500 um.) | ||||||
| Copyright | This image is from Rattner A, Proc Natl Acad Sci U S A 2013 Oct 1;110(40):E3830-E3839. Copyright 2013 National Academy of Sciences, U.S.A. J:201133 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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