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Caption | Genetic interaction analysis of Hivep3 (Shn3) with Runx2 in bone. (A, B) microCT analysis of the femurs from 10 week old wild-type (Shn3+/+), Runx2tm1Mjo/Runx2+ (Runx2+/-), Hivep3tm1Glm/Hivep3+ (Shn3+/-),Hivep3tm1Glm/Hivep3+ Runx2tm1Mjo/Runx2+ (Shn3+/-;Runx2+/-), Hivep3tm1Glm/Hivep3tm1Glm (Shn3-/-) and Hivep3tm1Glm/Hivep3tm1Glm Runx2tm1Mjo/Runx2+ (Shn3-/-;Runx2+/-) mice. Displayed are three-dimensional reconstructions of trabecular bone (A), and values for bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th). Values are mean + SD (B). (C) Radiographs of 6 week old mice of the indicated genotypes were taken to demonstrate clavicular hypoplasia. Arrows indicate clavicles. | ||||||||||
Copyright | This image is from Shim JH, J Clin Invest 2013 Sep 3;123(9):4010-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201597 | ||||||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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