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| Caption | Morphological evidence for aortic valvular stenosis in Klf3m1Cmhd/Klf3+ mice. (A) Histological sections showing thickened aortic valve leaflets in adult heterozygotes (arrow in center and right panels) vs. wild-type (WT; arrow in left panel). Blebs or hematomas were sometimes observed on aortic valve leaflets of heterozygous mutant mice (e.g. arrow in right panel). (B) Scanning electron microscopy images of adult aortic valves (arrows) from WT (left) and heterozygoous (center) mice, with magnified images of valve leaflets (right), that show thickened leaflets in mutant mice.(C) Micro-ultrasound images of aortic arch (Ao) in adult mutant (below) vs. WT (above) showing aortic dilatation in the left ventricular outflow tract (LVOT) typical of the mutant mice. (D) Elevated peak blood velocity in the ascending aorta of mutant (solid circles) relative to WT controls (open circles). Mean +/- SE are shown for each group. The lower dashed line shows the WT mean + 2SD and the upper dashed line the WT mean + 3SD. 20 of 31 mutants had peak velocities >3SD above WT. | ||||
| Copyright | This image is from Kelsey L, PLoS Genet 2013;9(7):e1003612, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206507 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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