Phenotype Image Detail

Image

Caption

Inflammation, dying hepatocytes and collagen deposition in Glmp^{Gt(P084H04)Wrst}/Glmp^{Gt(P084H04)Wrst} (Ncu-g1^gt/gt) liver. (A) Hematoxylin and eosin staining of liver sections from 6-month-old wild-type (WT) and mutant mice with a distorted tissue structure, massive infiltration of mononuclear leucocytes and granulocytes (long arrows), and acidophilic hepatocytes (short arrows, inset) in portal areas of mutant mice. Scale bar: 50 um. (B) Masson-Goldner's trichrome staining of liver sections from WT and mutant mice shows fibrosis in periportal regions of mutant mice (arrows), where connective tissue stains green. Scale bar: 50 um. (C) Representative transmission electron microscopy micrographs of perisinusoidal areas in liver sections from WT and mutant mice. Massive deposition of fibrous collagen is present in the space of Disse of the mutant liver (arrows) (C, collagen). Scale bars: 2 um.

This image is from Kong XY, Dis Model Mech 2014 Mar;7(3):351-62, and is displayed under the terms of the Creative Commons Attribution-Noncommerical-Share Alike 3.0 Unported License. J:208774

Associated
Alleles

Symbol	Name
Glmp^{Gt(P084H04)Wrst}	glycosylated lysosomal membrane protein; gene trap P084H04, German Gene Trap Consortium

Associated
Genotypes

Allelic Composition	Genetic Background
Glmp^{Gt(P084H04)Wrst}/Glmp^{Gt(P084H04)Wrst}	involves: 129S2/SvPas * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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