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| Caption | Atoh1trhl/Atoh1trhl (trhl/trhl) mice compared to wild-type (+/+) cerebellum morphology. Cerebellar abnormalities in H&E-stained and cresyl violet-counterstained sections through the cerebellum of a representative wild-type control (left panels) and a homozygous mutant (right panels) mouse shown under increasing magnification from 5X to 63X (n = 3 per group). Cerebella from each genotype were examined. The cerebellum in wild-type is well developed and foliated (A), but it is smooth (B) in homozygous mutant mice. The external granule layer (EGL) is indicated by the arrow in both middle panels. In (D) the EGL of the homozygous mutant mice is significantly underdeveloped as compared to (C). Under high magnification, the Purkinje cell layer (PCL), indicated by the star in both (E) and (F), appears disorganized in the mutant, with some Purkinje cells (asterisk in F) located deep in the cerebellum, where they are not normally found. | ||||
| Copyright | This image is from Sheykholeslami K, PLoS One 2013;8(11):e79791, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209662 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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