Phenotype Image Detail

Image

Caption

Adult Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} (-/-) mice exhibit mild cardiac dysfunction with increased valve annulus dimensions. Representative Doppler profile in the apical-4 chamber view of mitral valve inflow velocities (A-B) and mitral valve annulus measurement (E-F) from wild-type (+/+) (n=8) and homozygous mutant (n=9) mice. Box-and-whisker plots reveal normal fractional shortening (FS) and ejection fraction (EF) in mutant mice (C), but an increased Tei index (D) and increased mitral and tricuspid annulus dimensions to body weight ratios (G) as compared to controls, *p<0.01. A = late filling; AV = atrioventricular; E = early filling; ET = ejection time; IVCT = isovolumetric contraction time; IVRT = isovolumetric relaxation time; LV = left ventricle; MV = mitral valve; RV = right ventricle.

This image is from Krcmery J, PLoS One 2013;8(11):e80809, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209780

Associated
Alleles

Symbol	Name
Pdlim7^{Gt(OST445990)Lex}	PDZ and LIM domain 7; gene trap OST445990, Lexicon Genetics

Associated
Genotypes

Allelic Composition	Genetic Background
Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex}	B6.129S5-Pdlim7^{Gt(OST445990)Lex}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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