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| Caption | Atrioventricular valves of adult Pdlim7Gt(OST445990)Lex/Pdlim7Gt(OST445990)Lex (-/-) mice display abnormal morphology. Histological sections from 3-month old wild-type (+/+) and homozygous mutant hearts stained with Masson's Trichrome (A-D) and Alcian blue (E-F) exhibit normal distribution of collagens (blue, A-D) and glycosaminoglycans (blue, E-F), but elongated mitral valves in mutant mice (arrows, B, F; n=5) compared to wild-type controls (A, E; n=3). Scale bar = 100 um. Representative 3D reconstructions of serial sections of mitral (pink) and tricuspid (turquoise) valves from a wold-type (G) and mutant (H) mouse in the same anterodorsolateral perspective. Table providing quantification of increased surface area to volume ratios of atrioventricular valves in mutant (mitral, n=5; tricuspid, n=4) compared to wild-type (mitral, n=6; tricuspid, n=5) controls (I). *p<0.04. LV = left ventricle; MV = mitral valve; SA = surface area; TV = tricuspid valve; Vol = volume. | ||||
| Copyright | This image is from Krcmery J, PLoS One 2013;8(11):e80809, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209780 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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