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| Caption | Magi2tm1Key/Magi2tm1Key mice develop severe and diffuse glomerular extracapillary proliferations with focal epithelial crescent formation by 5.5 weeks of age. (A) Representative light microscopic images demonstrating morphologic changes in wild-type (+/+) mice at 11 days and 7 weeks of age. Glomeruli and tubulointerstitium show no significant pathologic changes (PAS staining). (Scale bars: 20 um.) (B) Representative light microscopic images demonstrating morphologic changes in mutant mice at 11 days, 3 weeks, 5.5 weeks, and 7 weeks of age. At 11 days, no significant light microscopic changes are observed. At 3 weeks, glomeruli show mild mesangial expansion and very focal intraglomerular cellular debris without obvious inflammation or hypercellularity, and the tubulointerstitium demonstrates no significant pathologic changes. By contrast, at 5.5 weeks of age, the majority of glomeruli show segmental or global extracapillary epithelial cell proliferations and focal collapse of the tuft (arrow), resembling a severe collapsing glomerulopathy. Some proliferations resemble a cellular or fibrocellular crescent (arrowhead). Tubules contain focal protein casts (asterisk), and the interstitium shows early fibrosis with only chronic interstitial inflammation. By 7 weeks, the majority of glomeruli are globally sclerosed with focal fibrous crescents, and the tubulointerstitium shows advanced chronic changes with chronic inflammation, tubular atrophy and interstitial fibrosis (PAS staining). (Scale bars: 20 um.) | ||||
| Copyright | This image is from Balbas MD, Proc Natl Acad Sci U S A 2014;111(41):14876-81. Copyright 2014 National Academy of Sciences, U.S.A. J:213553 | ||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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