Phenotype Image Detail

Image

Caption

Morphological and radiographic examination of Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} mice. A) 2-week-old mutant mice are growth retarded. 2-week-old mutant mice (C and E) also have a tooth eruption defect compared to their wild-type (WT) littermates (B and D). The white arrows (D and E) demonstrate the presence of tooth buds that failed to erupt in the mutant mice. Radiographic images demonstrate that 3-week-old mutant mice (G and I) have bones that lack marrow cavities. Compare the femur (white arrow) and pelvis (black arrow) with WT (F and H) mice. The metaphyseal cupping in the mutant femur and tibia (I) are consistent with rickets.

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated
Alleles

Symbol	Name
Snx10^{tm1a(EUCOMM)Raba}	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino

Associated
Genotypes

Allelic Composition	Genetic Background
Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba}	involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24