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Caption | Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba (Snx10 KD) and Tcirg1tm1Ypl/Tcirg1tm1Ypl (Atp6i KO) mice show a combined phenotype: osteopetrorickets. A) Radiographs (top and bottom panels) show that both mutant mice have bones with a higher radio-density and lack cortical bone. The metaphyseal fraying and cupping seen in the femur and tibia are features of rickets (bottom panels). B) MicroCT surface images of the femur show cortical bone deficiency, which produces a moth-eaten appearance and also confirms hypo-mineralization of condyles in both mutants. The white line in the longitudinal mid-plane sections (B, top) indicates the region where the transverse microCT images were taken (B, bottom). | ||||||
Copyright | This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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