| Image |
|
||||
| Caption | Morphological transformation in Ednratm7(Hand2)Hku/Ednra+ (EdnraHand2/+ chimera) ES cell-derived chimeric mice. (A) Representative surface appearance of E18.5 EdnraHand2/+ chimeric mice. EdnraHand2/+ chimeric mice demonstrate loss of vibrissae follicles, open eyelids (arrows), and polydactyly (arrowheads). (B-E) Craniofacial bone and cartilage elements of E18.5 Ednratm1Hku/Ednra+ (EdnraNeo/+) ES cell-derived (B) and EdnraHand2/+ ES cell-derived (C-E) chimeric mice. Whereas EdnraNeo/+-chimeric mice show normal skeletal morphology (B), EdnraHand2/+ chimeric mice demonstrate transformation of the maxilla into dentary-like bone (C), which fuses to the premaxilla and contains an ectopic incisor at the tip (D). The condylar and angular processes of the dentary, gonial, ectotympanic, and squamosal bones were often malformed or absent (E). (F-I) Craniofacial skeletons of E15.5 WT (F and H) and EdnraHand2/+ chimeric (G and I) mice. Ectopic formation of Meckelian cartilage (MC)-like, rod-shaped cartilage is present often with small and deformed ala temporalis in EdnraHand2/+-chimeric mice. The malleus, incus, stapes, and styloid process are deformed. agp, angular process; at, ala temporalis; cdp, condylar process; crp, coronoid process; dnt, dentary; etm, ectotympanic; fmx, frontal process of maxilla; gn, gonial; hy, hyoid; in, incus; jg, jugal; ma, malleus; mx, maxilla; pmx, premaxilla; sp, styloid process; sq, squamosal; st, stapes; UI, upper incisor; *, ectopic structure. | ||||
| Copyright | This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools