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| Caption | Spermatogenesis is disrupted in Setxtm1.1Mfl/Setxtm1.1Mfl (-/-) mice. A. Testes from 35-day-old wild-type (+/+) and mutant mice. B-C. Hematoxylin and eosin (H&E)-stained sections of testes from adults. Scale bar, 100 um. D-E. Enlarged images of regions in (B) and (C). Asterisks in (C) and (E) show vacuolated seminiferous tubules in which both spermatozoa and spermatids are absent. Scale bar, 100 um. F-G. H&E sections of epididymis from wild-type and mutant adult mice. While there are numerous spermatozoids (Spm) in wild-type epididymis, no sperm is present in mutant. Scale bar, 100 um. H. TUNEL stained sections of testes from adult WT and mutant mice. Many TUNEL-positive cells are observed in mutant testes. Scale bar, 50 um. (1) and (2) are magnifications of a seminiferous tubule. | ||||
| Copyright | This image is from Becherel OJ, PLoS Genet 2013 Apr;9(4):e1003435, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223053 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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