Phenotype Image Detail

Image

Caption

Crx^tm1.1Smgc/Crx^tm1.1Smgc (E168d2/d2) and Crx^tm2.1Smgc/Crx^tm2.1Smgc (R90W/W) mice develop Leber Congenital Amaurosis (LCA)-like retinopathy as seen in Crx^tm1Clc/Crx^tm1Clc (-/-) mice. A-L. H&E staining of paraffin embedded sagittal retinal sections for Crx^tm1.1Smgc/Crx^tm1.1Smgc, Crx^tm2.1Smgc/Crx^tm2.1Smgc, and Crx^tm1Clc/Crx^tm1Clc (-/-) mutant mice at P14, 1 month and 3 months and imaged by light microscopy, showing the lack of photoreceptor outer segments (OS) and loss of outer nuclear layer (ONL) cells with age.

This image is from Tran NM, PLoS Genet 2014 Feb;10(2):e1004111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:211011

Associated
Alleles

Symbol	Name
Crx^tm1.1Smgc	cone-rod homeobox; targeted mutation 1.1, Shiming Chen
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko
Crx^tm2.1Smgc	cone-rod homeobox; targeted mutation 2.1, Shiming Chen

Associated
Genotypes

Allelic Composition	Genetic Background
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac
Crx^tm1.1Smgc/Crx^tm1.1Smgc	B6.129X1(CBA)-Crx^tm1.1Smgc
Crx^tm2.1Smgc/Crx^tm2.1Smgc	B6.129X1(CBA)-Crx^tm2.1Smgc

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