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Phenotype Image Detail
Image
Caption Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi (Cep290LacZ/LacZ) mice exhibit progressive renal collecting duct cystic disease. Representative kidney sections from wild-type (Cep290+/+) (Upper) and mutant mice (Lower) stained with hematoxylin/eosin. Microcysts are present in mutant kidneys from birth to 1 year (A, and magnified in B) at birth (P0), (C) 2 weeks (P14), and (D) 1 year (1 yr) of age. The asterisk highlights collecting duct cysts, and arrows indicate the epithelial cell layer lining of a cyst. (Scale bars: A, 500 um; B, 50 um; C and D, 500 um.)
Copyright This image is from Hynes AM, Proc Natl Acad Sci U S A 2014 Jul 8;111(27):9893-8. Copyright 2014 National Academy of Sciences, U.S.A. J:212182
Associated
Alleles
Symbol Name
Cep290Gt(CC0582)Wtsi centrosomal protein 290; gene trap CC0582, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory