Phenotype Image Detail

Image

Caption

H&E-stained histological sections are shown. "Gal" indicates the Spo11^tm1.1Gvpc allele, "⁺" indicates the wild-type allele and "^-" indicates the null Spo11^tm3Rdco allele. A. Testes. Note the abundance of spermatocytes, but lack of spermatids in the seminiferous tubules of Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc (Spo11^Gal/Gal) mice; B. Epididymus. Note the lack of spermatozoa in the Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice; C. Ovaries. A few follicles are evident in the Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc 3 month old females, but none in the Spo11^tm1.1Gvpc/Spo11^tm3Rdco (Spo11^Gal/-) mice.

This image is from Smagulova F, BMC Genomics 2013;14():493, an open-access article, licensee BioMed Central Ltd. J:202231

Associated
Alleles

Symbol	Name
Spo11^tm1.1Gvpc	SPO11 initiator of meiotic double stranded breaks; targeted mutation 1.1, Galina Petukhova
Spo11^tm3Rdco	SPO11 initiator of meiotic double stranded breaks; targeted mutation 3, R Daniel Camerini-Otero

Associated
Genotypes

Allelic Composition	Genetic Background
Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: C57BL/6
Spo11^tm1.1Gvpc/Spo11^tm3Rdco	involves: C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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