Phenotype Image Detail

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Phenotype Image Detail

Image

Caption

The number of meiotic double stranded breaks (DSBs) is reduced in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc (Spo11^Gal/Gal) and Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco (Spo11^Gal/Gal Hop2^-/-) females. Chromosomal spreads from E15.5 ovaries were immunostained with antibodies to the DMC1 (red) and SCP3 (green) proteins.

This image is from Smagulova F, BMC Genomics 2013;14():493, an open-access article, licensee BioMed Central Ltd. J:202231

Associated
Alleles

Symbol	Name
Psmc3ip^tm1Rdco	proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein; targeted mutation 1, R Daniel Camerini-Otero
Spo11^tm1.1Gvpc	SPO11 initiator of meiotic double stranded breaks; targeted mutation 1.1, Galina Petukhova

Associated
Genotypes

Allelic Composition	Genetic Background
Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: C57BL/6
Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc	involves: 129S6/SvEvTac * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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