Phenotype Image Detail

Image

Caption

T cell-specific deletion of Tgfb1 results in increased organ inflammation and Th1-effector cytokine production. a-f: Hematoxylin and eosin staining of serial sections of lung (a-c) and salivary gland (d-f) from 5-month-old control (a,d), Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (flox-ex 6/flox-ex 6, Tg) (b,e) and Tgfb1^tm1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (flox-ex 6/-, Tg) (c,f) mice. These histopathology data are representative results of at least three mice per genotype analyzed. All photomicrographs are taken at equal magnification. Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (flox-ex 6/flox-ex 6, Tg) mice exhibit moderate inflammation in both the lungs (arrows in b) and the salivary gland (arrows in e) which becomes severe in both organs (arrows in c,f) in Tgfb1^tm1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (flox-ex 6/-, Tg) mice.

This image is from Azhar M, Genesis 2009 Jun;47(6):423-31, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:150024

Associated
Alleles

Symbol	Name
Tgfb1^tm1Doe	transforming growth factor, beta 1; targeted mutation 1, Thomas Doetschman
Tgfb1^tm2.1Doe	transforming growth factor, beta 1; targeted mutation 2.1, Thomas Doetschman
Tg(Lck-cre)548Jxm	transgene insertion 548, Jamey Marth

Associated
Genotypes

Allelic Composition	Genetic Background
Tg(Lck-cre)548Jxm/? Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA
Tgfb1^tm1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/?	involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

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