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| Caption | Abnormal heart development and coronary vasculogenesis after early cardiomyocyte-restricted Zfpm2 (Fog2) inactivation in Zfpm2tm1Sho/Zfpm2tm2Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ (Fog2NK) mice. (A and B) Control and littermate mutant embryos at E13.5. (C-H) Representative H&E staining of mutant (right panels) and littermate control (left panels) hearts at different levels. RA, right atrium; LA, left atrium; RV, right ventricle; A, aorta. The asterisk indicates atrioventricular (AV) cushion and the arrow indicates ventricular septal defect (VSD). (I-K) PECAM whole-mount staining of mutant and control hearts at E13.5. The coronary endothelial plexus coverage (ratio of region within black dotted line to total projected ventricular area) was significantly decreased in mutants. (*P < 0.05; n = 4-5 per group as indicated.) (L) Section of X-gal stained Tie2-Lz hearts showed decreased coronary vessels in the compact myocardial layer of mutant compared with littermate control. Scale bar: 500 um. Ventricles in the boxed regions are magnified (right panels). | ||||||||
| Copyright | This image is from Zhou B, J Clin Invest 2009 Jun;119(6):1462-76 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150452 | ||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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