Phenotype Image Detail

Image

Caption

(D) Injected Microfil demonstrated reduced coronary microvasculature in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 mice (Gata4^ki-MC) hearts compared with littermate Gata4⁺/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 (Gata4^+/fl Myh6-Cre) control. Scale bar: 1 mm (top panels); 200 um (bottom panels). (E) PECAM staining revealed decreased capillary density in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 mice (Gata4^ki-MC) hearts compared with controls (n = 3). (F) SMA staining revealed decreased arteriole density in mutant hearts compared with controls (n = 3). (G) Fibronectin and collagen III staining revealed significantly increased fibrosis in mutant hearts compared with controls (n = 3). Scale bar: 100 um. *P < 0.05.

This image is from Zhou B, J Clin Invest 2009 Jun;119(6):1462-76 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150452

Associated
Alleles

Symbol	Name
Gata4^tm1.1Wtp	GATA binding protein 4; targeted mutation 1.1, William T Pu
Gata4^tm1Sho	GATA binding protein 4; targeted mutation 1, Stuart Orkin
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider

Associated
Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Sho/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd

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