Phenotype Image Detail

Image

Caption

Ablation of Spp1 correlates with reductions in diaphragm and cardiac fibrosis. Micrographs show representative trichrome staining of diaphragms from Dmd^mdx/Dmd^mdx or Dmd^mdx/Y (left panels) and Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh or Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh (DMM, right panels) animals. The top 2 panels are of 6-month-old mice, whereas bottom 2 panels are of 7-month-old mice. Areas of blue staining indicate proliferation of ECM (i.e., fibrosis), and areas of red staining indicate muscle tissue. Original magnification, x20.

This image is from Vetrone SA, J Clin Invest 2009 Jun;119(6):1583-94 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150572

Associated
Alleles

Symbol	Name
Dmd^mdx	dystrophin, muscular dystrophy; X linked muscular dystrophy
Spp1^tm1Blh	secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan

Associated
Genotypes

Allelic Composition	Genetic Background
Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24