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| Caption | Homozygous deletion of Trim33 (Tif1gamma) cooperates with activated KrasG12D mutation to induce cystic tumors of the pancreas in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox) mice. Homozgyous deletion of Cdkn2a cooperates with activated KrasG12D mutation to induce solid tumors in Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;LSL-KrasG12D;Ink4A/Arflox/lox). Magnetic Resonance Imaging (MRI) (A-C). Positron Emission Tomography (PET) (D-F). Gross anatomy of the pancreas after dissection (G-I). Hematoxylin Phloxine Saffron (HPS) staining of pancreas sections (J-L). Acinar tissue (stars), scattered endocrine islets (arrow) and exocrine ducts (arrowhead). When notified, pancreas is circled in red dashed lines. Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox mice used in this experiment were 154 days old and representative of the 4 mice we analyzed at the age of 18-27 weeks. | ||||||||||
| Copyright | This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781 | ||||||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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