Phenotype Image Detail

Image

Caption

Inactivation of Trim33 (Tif1gamma) accelerates activated Kras^G12D-mediated pancreatic neoplasia. Sections of wild-type (A-D), Kras^tm4Tyj/Kras^tm4Tyj Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre LSL-Kras^G12D) (E-H) and Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre LSL-Kras^G12D Tif1gamma^lox/lox) (I-L) pancreas from mice at different ages were stained with hematoxylin phloxine saffron (HPS). Number of mice: 3 weeks, n = 3; 6-13 weeks, n = 5; 18-27 weeks, n = 4. Inset pictures: Higher magnification.

This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781

Associated
Alleles

Symbol	Name
Kras^tm4Tyj	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Tg(Pdx1-cre)89.1Dam	transgene insertion 89.1, Douglas A Melton
Trim33^tm1Los	tripartite motif-containing 33; targeted mutation 1, Regine Losson

Associated
Genotypes

Allelic Composition	Genetic Background
Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Kras^tm4Tyj/Kras^tm4Tyj Tg(Pdx1-cre)89.1Dam/0	involves: 129S4/SvJae * C57BL/6 * DBA/2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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