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| Caption | Wnt Overexpression in the ureteric bud leads to kidney agenesis. Expression of a stabilized allele of beta-catenin, Ctnnb1tm1Mmt, in the Wollfian duct using Tg(Hoxb7-cre)13Amc (HoxB7Cre) to activate transgene expression phenocopies the Lrp4 knockout phenotype with both uni- and bilateral kidney agenesis (a-c) in Ctnnb1tm1Mmt/Ctnnb1+ Tg(Hoxb7-cre)13Amc/0 (Hoxb7-cre; Catnbexon3flox/+) mice. The formation of the Wolffian duct and distal ureters as well as bladder and adrenal glands remained unaffected. The asterisks (a and b) indicate the position of regular kidneys. The arrows (b and c) indicate the predicted position of kidneys that have not formed. | ||||||
| Copyright | This image is from Karner CM, PLoS One 2010;5(4):e10418, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160547 | ||||||
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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