Phenotype Image Detail

Image

Caption

Spermatid differentiation arrest, germ cell sloughing and apoptosis lead to sterility in the Rbm5^sda/Rbm5^sda males. (A) Intact testes and (B) testis weight of wild-type (WT/WT) and mutant (sda/sda) adult mice (8-week-old). (C) Periodic acid-Schiff stained testis sections at stage VII-VIII and (D) haematoxylin and eosin stained epididymis sections of WT and mutant adult mice. PS: pachytene spermatocyte, rST: round spermatid, eST: elongating and elongated spermatids; Sp: spermatozoa. D, arrowheads indicate sloughed immature germ cells. (E) Caspase 3 (CASP3) and (F) Caspase 9 (CASP9) immunostaining of WT and mutant adult testes. Brown staining represents apoptotic cells. (G) Numbers of Caspase 3 and (H) Casapse 9 positive cells per seminiferous tubule of WT and mutant adult testes. *p<0.01 (unpaired t-test).

This image is from O'Bryan MK, PLoS Genet 2013;9(7):e1003628, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223049

Associated
Alleles

Symbol	Name
Rbm5^sda	RNA binding motif protein 5; spermatid differentiation arrest

Associated
Genotypes

Allelic Composition	Genetic Background
Rbm5^sda/Rbm5^sda	involves: C57BL/6J * CBA

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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