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Phenotype Image Detail
Image
Caption Intrinsic failure of Mad2l2tm1Mpz/Mad2l2tm1Mpz Tg(Prdm1-cre)1Masu/0 primordial germ cells (PGCs). Apoptosis (TUNEL assay) in E8.75 embryo sections of hindgut endoderm after the conditional knockout of Mad2l2 by Prdm1-Cre. SSEA1-expressing PGCs are marked by arrowheads. Note the apoptotic and non-apoptotic PGC in knockout section. Arrow points to an SSEA1-negative apoptotic cell in the conditional knockout section. Scale bar, 20 um.
Copyright This image is from Pirouz M, PLoS Genet 2013 Aug;9(8):e1003712, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223048
Associated
Alleles
Symbol Name
Mad2l2tm1Mpz MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Mehdi Pirouz
Tg(Prdm1-cre)1Masu transgene insertion 1, M Azim Surani
Associated
Genotypes
Allelic Composition Genetic Background
Mad2l2tm1Mpz/Mad2l2tm1Mpz
Tg(Prdm1-cre)1Masu/0
involves: 129S2/SvPas * C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory