Phenotype Image Detail

Image

Caption

(A) Skeletal stain at P0 showing hindlimb and forelimb phalange development in the wild-type, Sostdc1^tm2Snd/Sostdc1^tm2Snd (Wise^-/-), Lrp5^tm1Kry/Lrp5^tm1Kry (Lrp5^-/-), Sostdc1^tm2Snd/Sostdc1^tm2Snd Lrp5^tm1Kry/Lrp5^tm1Kry (Wise^-/-:Lrp5^-/-) and Lrp6+/- strains. (B) Asterisks (*) highlight an increase in the ossification centers of digits 4 and 5 of the hindlimb in Wise^-/- mutants compared to the other strains. This Wise^-/- mutant phenotype in digits is partially rescued in an Lrp5^-/- strain showing an epistatic relationship between Wise and Lrp5. n = at least 5.

This image is from Ellies DL, PLoS One 2014;9(5):e96257, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:216098

Associated
Alleles

Symbol	Name
Lrp5^tm1Kry	low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
Sostdc1^tm2Snd	sclerostin domain containing 1; targeted mutation 2, Scott Sunders

Associated
Genotypes

Allelic Composition	Genetic Background
Sostdc1^tm2Snd/Sostdc1^tm2Snd	involves: 129S/SvEv
Lrp5^tm1Kry/Lrp5^tm1Kry Sostdc1^tm2Snd/Sostdc1^tm2Snd	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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