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| Caption | Trex1tm1.1Fwpe/Trex1tm1.1Fwpe mice have an autoimmune phenotype. Wild-type (WT) and Trex1tm1.1Fwpe/Trex1tm1.1Fwpe (D18N/D18N) (D) Spleen H&E, (Scale bar, 100 um); (E) Heart H&E (Scale bar, 100 um); (F) Kidney H&E, (Scale bar, 50 um; * indicates tubular proteinosis); and (G) Splenic vesel H&E (Bar, 50 um). Histologic analysis of tissues collected from mutant mice reveal four major categories of consistently observed lesions that are the most severe at 6 months of age, including lymphoid hyperplasia, inflammation, vasculitis, and kidney disease. | ||||
| Copyright | This image is from Grieves JL, Proc Natl Acad Sci U S A 2015 Apr 21;112(16):5117-22. Copyright 2015 National Academy of Sciences, U.S.A. J:220965 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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