Phenotype Image Detail

Image

Caption

Deletion of Brca2 from prostate epithelia results in hyperplasia and low-grade prostate intraepithelial neoplasia (LG PIN). (A) Haematoxylin and eosin stained sections of dorsolateral prostate (DLP), ventral prostate (VP) and anterior prostate (AP) of control and Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0 (Brca2^F/F;PBCre4)) mutants. Control (Brca2^F/F) and Brca2 heterozygous (Brca2^F/+;PBCre4) prostates do not have PIN. Prostate-specific homozygous deletion of Brca2 (Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0) results in focal hyperplasia and LG PIN (indicated with arrows). Black box shows the area shown in higher magnification in the panel below. (B) Detail of LG PIN in the DLP of Brca2 mutant prostates. Left panel shows a lumen with tufting pattern and right panel shows cribiform pattern. Arrowheads indicate atypical cells.

This image is from Francis JC, PLoS Genet 2010;6(6):e1000995, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161511

Associated
Alleles

Symbol	Name
Brca2^tm1Brn	breast cancer 2, early onset; targeted mutation 1, Anton Berns
Tg(Pbsn-cre)4Prb	transgene insertion 4, Pradip Roy-Burman

Associated
Genotypes

Allelic Composition	Genetic Background
Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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