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Caption | Characteristics of Herc1tbl/Herc1tbl (tbl/tbl) mice. Hind limbs clasping reflex (A) and rotarod performance (B) of mutant and control (+/+) mice. Data show mean +/- s.d. *** p < 0.001. (C) H&E stained sections of the cerebellum of a control mouse aged two months. (D-F) H&E sections of the cerebellum of mutant mice aged respectively of 1, 2, and 3 months (M), exhibiting Purkinje cell degeneration. Anti-calbindin D28-k staining of parasagittal sections of a normal (G, I) and mutant (H, J) mouse cortex aged 4 months. The cortex of the mutant mouse is almost completely depleted of Purkinje cells (PCs). Scale bars: (G, H) 500 um; (I, J) 25 um. | ||||
Copyright | This image is from Mashimo T, PLoS Genet 2009 Dec;5(12):e1000784, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161738 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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