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| Caption | Morphology of unfixed sperm in Pick1tm1Rlh/Pick1tm1Rlh (-/-) mice. Sperm from the mutant mice lose the typical hook-shaped head of normal sperm; instead, they have round or irregular ball-like heads. In addition, defects in the tail can also be seen in sperm from mutant mice. (F) Immunostaining of acrosome matrix protein Zp3r (sp56, red) and nucleus (nu, blue) in sperm. The acrosomes from mutant mice fail to acquire the crescent moon-shaped structure, are frequently fragmented, and are located in the wrong position. (G) Immunostaining of the mitochondrial sheath (ms, red) and nucleus in sperm. Mitochondrial sheaths in mutant mice display various defects, including (left to right) abnormal sperm with aggregated mitochondrial sheaths, split mitochondrial sheaths, the mitochondrial sheath overlapping with the round nucleus, and the mitochondrial sheath wrapping around the round nucleus. Scale bars: 5 um. | ||||
| Copyright | This image is from Xiao N, J Clin Invest 2009 Apr;119(4):802-12 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149846 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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